Dapsone hypersensitivity syndrome causing disseminated intravascular coagulation.

Severe dapsone hypersensitivity syndrome in a child

Dapsone (4,4'-diaminodiphenylsulfone, DDS), a potent anti-inflammatory agent, is widely used in the treatment of leprosy and several chronic inflammatory skin diseases. Dapsone therapy rarely results in development of dapsone hypersensitivity syndrome, which is characterized by fever, hepatitis, generalized exfoliative dermatitis, and lymphadenopathy. Here, we describe the case of an 11-year-ol...

Disseminated Intravascular Coagulation in a Case of Brucellosis Misdiagnosed as Thrombotic Thrombocytopenia Purpura

Acute Disseminated Intravascular Coagulation in Neuroendocrine Carcinoma

Malignancy is a common cause of disseminated intravascular coagulation and usually presents as a chronic disorder in solid organ tumours. We present a rare case of recurrent acute disseminated intravascular coagulation in neuroendocrine carcinoma after manipulation, firstly, by core biopsy and, later, by cytotoxic therapy causing a release of procoagulants and cytokines from lysed tumour cells....

Vitreous hemorrhages and disseminated intravascular coagulation in the newborn.

Of 164 consecutive newborns seen in consultations, three babies had either a preretinal or a vitreous hemorrhage, a rare occurrence. Two of these babies had a mild form of disseminated intravascular coagulation. The hemorrhages cleared within a few months after birth. Each of the three babies was premature, had a respiratory distress syndrome, and was born to a primiparous mother. The possibil...

Microvascular thrombosis and multiple organ dysfunction syndrome.

This paper will review the involvement of disseminated intravascular coagulation-induced microvascular thrombosis in the pathogenesis of multiple organ dysfunction syndrome and the interaction between disseminated intravascular coagulation and systemic inflammatory response syndrome in critically ill patients. The published literature on clinical and experimental studies are the data sources of...